Wonder how the GLP-1 Bashers feel about this?

Wonder how the GLP-1 Bashers feel about this?

“Our study data suggest that diabetic patients taking a particular class of medications are less likely to develop heart failure.” This statement comes from Henry Ford researcher and cardiologist David Lanfear, MD, who was the lead author of a study that concluded that GLP-1 usage could also help protect patients from developing heart failure.

The study look at more than 4,400 patients 1,488 of whom were taking GLP-1 drugs, Januvia, Victoza and Byetta, and 2,939 patients who were not. The study discovered that those who were taking GLP-1 drugs were more than 40 percent less likely to be hospitalized due to heart failure than those taking other blood sugar-lowering substance. The study also found a correlation between the use of GLP1 medications and a reduced risk of hospitalization for heart failure or any other reason, as well as a lower fatality rate.

This comes as welcome news for the entire class of GLP-1 drugs as they have come under attack recently with some dubious studies which attempt to link the class to an increased incidence of pancreatitis. Given the preoccupation with diabetes drugs and cardiovascular risks, one has to wonder how these GLP-1 bashers, most notably Dr. Peter Butler and his partners in crime, feel about this study. We’re also wondering how that crusading cardiologist Dr. Steven Nissen, the creator of the Avandia controversy, feels about this study as well.

Now for everyone waiting for comment by any of the zealots, don’t hold your breath because if there is one thing all these zealots share, besides loving the media spotlight, is a strange aversion to speaking with the media when it questions their anti-GLP-1 findings. People like Dr. Butler and Dr. Nissen just can’t seem to grasp the fact that someone would dare to question their intelligence. They seem to believe that just because they say something is so, that everyone else should just accept their questionable findings without any questions or further investigation. That it is an act of heresy to even question that their dubious findings may have flaws. Heaven help anyone who points out that their work has created a nightmare for any company looking to develop and get approved a new drug for type 2 diabetes.

But their displeasure and despise doesn’t stop there, just try and mention to them that all drugs carry some degree of risk and that diabetes is serious disease, which when uncontrolled, leads to serious co-morbidities and complications.  For people who have advanced degrees, published numerous studies and are held in high regard in some circles, they seem to forget that one of the cornerstones of scientific research is to spur spirited debate. This is especially true when their particular work does not prove definitively that there is a causal relationship between GLP-1 usage and pancreatitis. As we have noted on several occasions looking over the numerous studies done on the subject about the only thing that can said with any certainty is that no one really knows for sure.

This is not necessarily a bad thing as there are just some things that cannot be proven conclusively and this is one of those things. Yet it amazes Diabetic Investor that these zealots seem to believe that the physicians who treat patients with diabetes are too lazy to discuss with their patients the risks and rewards of the medications they are taking. The harsh reality is these physicians who treat patients with diabetes are often placed between the proverbial rock and a hard place. On the one hand they know from experience what happens when patients fail to control their diabetes. On the other, they are well aware that drugs, no matter how well they are studied sometimes do lead to adverse events. For physicians it’s a delicate balancing act doing their best to help their patients control their diabetes while at the same time doing their best to insure that the drugs they are prescribing are safe. When the study data is inconclusive, it comes down to their judgment and experience.

It is this last part that drives the zealots crazy, as they believe they should be the ones telling everyone else what to do ultimately taking the decision on which drugs to prescribe out of the hands of the physicians. This isn’t what the American healthcare system is supposed to be about, nor should it be. It would be different if there was clear and conclusive scientific evidence as then the decision becomes easy, however lacking this ultimately the decision on which drugs to use comes down to a discussion between the patient and the physician.

The truth is these zealots are the equivalent of third world dictators who try and stifle independent thought or as the great Winston Churchill said; “A modern dictator with the resources of science at his disposal can easily lead the public on from day to day, destroying all persistency of thought and aim, so that memory is blurred by the multiplicity of daily news and judgment baffled by its perversion.”